The subject of this paper is the development of entrepreneurship and entrepreneurial infrastructure of the Sisak-Moslavina County. The paper defines and explains the concepts of entrepreneurship, enterprises, entrepreneurial infrastructure and analyses the development of entrepreneurship in the Sisak-Moslavina County, with an emphasis on the town of Petrinja. An analysis of the available data has led to conclusions regarding the current state of entrepreneurship in this area. One of the factors influencing the greater start-up and development of entrepreneurship in Sisak-Moslavina County is the lack of able-bodied persons to start an entrepreneurial venture. Despite the county offering funding, individuals are afraid to enter into an entrepreneurial venture for fear of failure. Most entrepreneurs in the county are trying to find something new for citizens that would interest them and have a beneficial effect. Entrepreneurs start new businesses, but they don't last long. Possible perspectives for entrepreneurship development in this area depend on future demographic trends, as well as on the empowerment of supportive entrepreneurial institutions.